Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
Identifieur interne : 001B24 ( Main/Exploration ); précédent : 001B23; suivant : 001B25Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
Auteurs : Qiao Fan [Singapour] ; Virginie J. M. Verhoeven [Pays-Bas] ; Robert Wojciechowski [États-Unis] ; Veluchamy A. Barathi [Singapour] ; Pirro G. Hysi [Royaume-Uni] ; Jeremy A. Guggenheim [Royaume-Uni] ; René Höhn [Allemagne, Suisse] ; Veronique Vitart ; Anthony P. Khawaja [Royaume-Uni] ; Kenji Yamashiro [Japon] ; S Mohsen Hosseini [Canada] ; Terho Lehtim Ki [Finlande] ; Yi Lu [Australie] ; Toomas Haller [Estonie] ; Jing Xie [Australie] ; Cécile Delcourt [France] ; Mario Pirastu [Italie] ; Juho Wedenoja [Finlande] ; Puya Gharahkhani [Australie] ; Cristina Venturini [Royaume-Uni] ; Masahiro Miyake [Japon] ; Alex W. Hewitt [Australie] ; Xiaobo Guo [République populaire de Chine] ; Johanna Mazur [Allemagne] ; Jenifer E. Huffman ; Katie M. Williams [Royaume-Uni] ; Ozren Polasek [Croatie] ; Harry Campbell ; Igor Rudan ; Zoran Vatavuk [Croatie] ; James F. Wilson ; Peter K. Joshi ; George Mcmahon [Royaume-Uni] ; Beate St Pourcain [Royaume-Uni, Pays-Bas] ; David M. Evans [Royaume-Uni, Australie] ; Claire L. Simpson [États-Unis] ; Tae-Hwi Schwantes-An [États-Unis] ; Robert P. Igo [États-Unis] ; Alireza Mirshahi [Allemagne] ; Audrey Cougnard-Gregoire [France] ; Céline Bellenguez [France] ; Maria Blettner [Allemagne] ; Olli Raitakari [Finlande] ; Mika K Hönen [Finlande] ; Ilkka Seppala [Finlande] ; Tanja Zeller [Allemagne] ; Thomas Meitinger [Allemagne] ; Janina S. Ried [Allemagne] ; Christian Gieger [Allemagne] ; Laura Portas [Italie] ; Elisabeth M. Van Leeuwen [Pays-Bas] ; Najaf Amin [Pays-Bas] ; André G. Uitterlinden [Pays-Bas] ; Fernando Rivadeneira [Pays-Bas] ; Albert Hofman [Pays-Bas] ; Johannes R. Vingerling [Pays-Bas] ; Ya Xing Wang [République populaire de Chine] ; Xu Wang [Singapour] ; Eileen Tai-Hui Boh [Singapour] ; M. Kamran Ikram [Singapour] ; Charumathi Sabanayagam [Singapour] ; Preeti Gupta [Singapour] ; Vincent Tan [Singapour] ; Lei Zhou [Singapour] ; Candice E. H. Ho [Singapour] ; Wan'E Lim [Singapour] ; Roger W. Beuerman [Singapour] ; Rosalynn Siantar [Singapour] ; E-Shyong Tai [Singapour] ; Eranga Vithana [Singapour] ; Evelin Mihailov [Estonie] ; Chiea-Chuen Khor [Singapour] ; Caroline Hayward ; Robert N. Luben [Royaume-Uni] ; Paul J. Foster [Royaume-Uni] ; Barbara E. K. Klein [États-Unis] ; Ronald Klein [États-Unis] ; Hoi-Suen Wong [Canada] ; Paul Mitchell [Australie] ; Andres Metspalu [Estonie] ; Tin Aung [Singapour] ; Terri L. Young [États-Unis] ; Mingguang He [République populaire de Chine] ; Olavi P Rssinen [Finlande] ; Cornelia M. Van Duijn [Pays-Bas] ; Jie Jin Wang [Australie] ; Cathy Williams [Royaume-Uni] ; Jost B. Jonas [République populaire de Chine, Allemagne] ; Yik-Ying Teo [Singapour] ; David A. Mackey [Australie] ; Konrad Oexle [Allemagne] ; Nagahisa Yoshimura [Japon] ; Andrew D. Paterson [Canada] ; Norbert Pfeiffer [Allemagne] ; Tien-Yin Wong [Singapour] ; Paul N. Baird [Australie] ; Dwight Stambolian [États-Unis] ; Joan E. Bailey Wilson [États-Unis] ; Ching-Yu Cheng [Singapour] ; Christopher J. Hammond [Royaume-Uni] ; Caroline C. W. Klaver [Pays-Bas] ; Seang-Mei Saw [Singapour] ; Jugnoo S. Rahi [Royaume-Uni] ; Jean-François Korobelnik [France] ; John P. Kemp [Royaume-Uni] ; Nicholas J. Timpson [Royaume-Uni] ; George Davey Smith [Royaume-Uni] ; Jamie E. Craig [Australie] ; Kathryn P. Burdon [Australie] ; Rhys D. Fogarty [Australie] ; Sudha K. Iyengar [États-Unis] ; Emily Chew [États-Unis] ; Sarayut Janmahasatian [États-Unis] ; Nicholas G. Martin [Australie] ; Stuart Macgregor [Australie] ; Liang Xu [République populaire de Chine] ; Maria Schache [Australie] ; Vinay Nangia [Inde] ; Songhomitra Panda-Jonas [Inde] ; Alan F. Wright ; Jeremy R. Fondran [États-Unis] ; Jonathan H. Lass [États-Unis] ; Sheng Feng [États-Unis] ; Jing Hua Zhao [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Nick J. Wareham [Royaume-Uni] ; Taina Rantanen [Finlande] ; Jaakko Kaprio [Finlande] ; Chi Pui Pang [Hong Kong] ; Li Jia Chen [Hong Kong] ; Pancy O. Tam [Hong Kong] ; Vishal Jhanji [Hong Kong] ; Alvin L. Young [Hong Kong] ; Angela Döring [Allemagne] ; Leslie J. Raffel [États-Unis] ; Mary-Frances Cotch [États-Unis] ; Xiaohui Li [États-Unis] ; Shea Ping Yip [Hong Kong] ; Maurice K. H. Yap [Hong Kong] ; Ginevra Biino [Italie] ; Simona Vaccargiu [Italie] ; Maurizio Fossarello [Italie] ; Brian Fleck [Royaume-Uni] ; Seyhan Yazar [Australie] ; Jan Willem L. Tideman [Pays-Bas] ; Milly Tedja [Pays-Bas] ; Margaret M. Deangelis [États-Unis] ; Margaux Morrison [États-Unis] ; Lindsay Farrer [États-Unis] ; Xiangtian Zhou [République populaire de Chine] ; Wei Chen [République populaire de Chine] ; Nobuhisa Mizuki [Japon] ; Akira Meguro [Japon] ; Kari Matti M Kel [Finlande]Source :
- Nature Communications [ 2041-1723 ] ; 2016.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Environnement, Humains, Locus génétiques, Niveau d'instruction, Polymorphisme de nucléotide simple (génétique), Population d'origine asiatique (génétique), Population d'origine européenne (génétique), Prédisposition génétique à une maladie, Troubles de la réfraction oculaire (génétique), Étude d'association pangénomique.
- MESH :
- génétique : Polymorphisme de nucléotide simple, Population d'origine asiatique, Population d'origine européenne, Troubles de la réfraction oculaire.
- Analyse de profil d'expression de gènes, Environnement, Humains, Locus génétiques, Niveau d'instruction, Prédisposition génétique à une maladie, Étude d'association pangénomique.
English descriptors
- KwdEn :
- Asian Continental Ancestry Group (genetics), Educational Status, Environment, European Continental Ancestry Group (genetics), Gene Expression Profiling, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide (genetics), Refractive Errors (genetics).
- MESH :
Abstract
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (
Url:
DOI: 10.1038/ncomms11008
PubMed: 27020472
PubMed Central: 4820539
Affiliations:
- Allemagne, Australie, Canada, Croatie, Estonie, Finlande, France, Hong Kong, Inde, Italie, Japon, Pays-Bas, Royaume-Uni, République populaire de Chine, Singapour, Suisse, États-Unis
- Angleterre, Angleterre de l'Est, Aquitaine, Finlande-Centrale, Grand Londres, Nouvelle-Aquitaine, Uusimaa
- Bordeaux, Cambridge, Helsinki, Jyväskylä, Londres, Sha Tin
- University College de Londres, Université chinoise de Hong Kong, Université d'Helsinki, Université de Bordeaux, Université de Cambridge, Université de Jyväskylä
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Le document en format XML
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Khawaja</name><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0SR,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yamashiro, Kenji" sort="Yamashiro, Kenji" uniqKey="Yamashiro K" first="Kenji" last="Yamashiro">Kenji Yamashiro</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine</institution>, Kyoto 6068507,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hosseini, S Mohsen" sort="Hosseini, S Mohsen" uniqKey="Hosseini S" first="S Mohsen" 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last="Lu">Yi Lu</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston</institution>, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haller, Toomas" sort="Haller, Toomas" uniqKey="Haller T" first="Toomas" last="Haller">Toomas Haller</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Estonian Genome Center, University of Tartu</institution>, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne</institution>, Melbourne, Victoria 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Delcourt, Cecile" sort="Delcourt, Cecile" uniqKey="Delcourt C" first="Cécile" last="Delcourt">Cécile Delcourt</name><affiliation wicri:level="1"><nlm:aff id="a20"><institution>Université de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement)</institution>, Bordeaux 33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a21"><institution>INSERM, U1219-Bordeaux Population Health Research Center</institution>, Bordeaux 33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Institute of Population Genetics, National Research Council</institution>, Sassari 07100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wedenoja, Juho" sort="Wedenoja, Juho" uniqKey="Wedenoja J" first="Juho" last="Wedenoja">Juho Wedenoja</name><affiliation wicri:level="1"><nlm:aff id="a23"><institution>Department of Public Health, University of Helsinki</institution>, Helsinki 00014,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Ophthalmology, University of Helsinki and Helsinki University Hospital</institution>, Helsinki 00014,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston</institution>, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a25"><institution>UCL Institute of Ophthalmology</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miyake, Masahiro" sort="Miyake, Masahiro" uniqKey="Miyake M" first="Masahiro" last="Miyake">Masahiro Miyake</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine</institution>, Kyoto 6068507,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne</institution>, Melbourne, Victoria 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>, Hobart, Tasmania 7000,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guo, Xiaobo" sort="Guo, Xiaobo" uniqKey="Guo X" first="Xiaobo" last="Guo">Xiaobo Guo</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Department of Statistical Science, School of Mathematics and Computational Science, Sun Yat-Sen University</institution>, Guangzhou 510275,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mazur, Johanna" sort="Mazur, Johanna" uniqKey="Mazur J" first="Johanna" last="Mazur">Johanna Mazur</name><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz</institution>, 55131 Mainz,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huffman, Jenifer E" sort="Huffman, Jenifer E" uniqKey="Huffman J" first="Jenifer E." last="Huffman">Jenifer E. Huffman</name><affiliation><nlm:aff id="a12"><institution>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Williams, Katie M" sort="Williams, Katie M" uniqKey="Williams K" first="Katie M." last="Williams">Katie M. Williams</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Department of Ophthalmology, King's College London</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Faculty of Medicine, University of Split</institution>, Split 21000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="a31"><institution>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh</institution>, Teviot Place, Edinburgh EH8 9AG,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="a31"><institution>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh</institution>, Teviot Place, Edinburgh EH8 9AG,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Vatavuk, Zoran" sort="Vatavuk, Zoran" uniqKey="Vatavuk Z" first="Zoran" last="Vatavuk">Zoran Vatavuk</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Ophthalmology, Sisters of Mercy University Hospital</institution>, Zagreb 10000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="a31"><institution>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh</institution>, Teviot Place, Edinburgh EH8 9AG,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation><nlm:aff id="a31"><institution>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh</institution>, Teviot Place, Edinburgh EH8 9AG,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name><affiliation wicri:level="1"><nlm:aff id="a33"><institution>MRC Integrative Epidemiology Unit (IEU), University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a34"><institution>School of Social and Community Medicine, University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="St Pourcain, Beate" sort="St Pourcain, Beate" uniqKey="St Pourcain B" first="Beate" last="St Pourcain">Beate St Pourcain</name><affiliation wicri:level="1"><nlm:aff id="a33"><institution>MRC Integrative Epidemiology Unit (IEU), University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a34"><institution>School of Social and Community Medicine, University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Max Planck Institute for Psycholinguistics</institution>, Wundtlaan 1, 6525 XD Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation wicri:level="1"><nlm:aff id="a33"><institution>MRC Integrative Epidemiology Unit (IEU), University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a34"><institution>School of Social and Community Medicine, University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a36"><institution>University of Queensland Diamantina Institute, Translational Research Institute</institution>, Brisbane, Queensland 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simpson, Claire L" sort="Simpson, Claire L" uniqKey="Simpson C" first="Claire L." last="Simpson">Claire L. Simpson</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health</institution>, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a37"><institution>Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center</institution>, Memphis, Tennessee 38163,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schwantes An, Tae Hwi" sort="Schwantes An, Tae Hwi" uniqKey="Schwantes An T" first="Tae-Hwi" last="Schwantes-An">Tae-Hwi Schwantes-An</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health</institution>, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Igo, Robert P" sort="Igo, Robert P" uniqKey="Igo R" first="Robert P." last="Igo">Robert P. Igo</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Department of Epidemiology and Biostatistics, Case Western Reserve University</institution>, Cleveland, Ohio 44106,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mirshahi, Alireza" sort="Mirshahi, Alireza" uniqKey="Mirshahi A" first="Alireza" last="Mirshahi">Alireza Mirshahi</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Ophthalmology, University Medical Center Mainz</institution>, 55131 Mainz,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Dardenne Eye Hospital, Bonn-Bad Godesberg</institution>, 53177 Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cougnard Gregoire, Audrey" sort="Cougnard Gregoire, Audrey" uniqKey="Cougnard Gregoire A" first="Audrey" last="Cougnard-Gregoire">Audrey Cougnard-Gregoire</name><affiliation wicri:level="1"><nlm:aff id="a20"><institution>Université de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement)</institution>, Bordeaux 33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a21"><institution>INSERM, U1219-Bordeaux Population Health Research Center</institution>, Bordeaux 33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Inserm, U1167</institution>, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Univ. Lille, U1167</institution>, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a42"><institution>Université Lille 2</institution>, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blettner, Maria" sort="Blettner, Maria" uniqKey="Blettner M" first="Maria" last="Blettner">Maria Blettner</name><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz</institution>, 55131 Mainz,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="a43"><institution>Research Centre of Applied and Preventive Medicine, University of Turku</institution>, Turku 20520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital</institution>, Turku 20520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Department of Clinical Physiology, Tampere University Hospital and School of Medicine, University of Tampere</institution>, Tampere 33520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seppala, Ilkka" sort="Seppala, Ilkka" uniqKey="Seppala I" first="Ilkka" last="Seppala">Ilkka Seppala</name><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere</institution>, Tampere 33520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>Clinic for General and Interventional Cardiology, University Heart Center Hamburg</institution>, 20246 Hamburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><affiliation wicri:level="1"><nlm:aff id="a47"><institution>Institute of Human Genetics, Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a48"><institution>Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München</institution>, 81675 Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S." last="Ried">Janina S. Ried</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Institute of Population Genetics, National Research Council</institution>, Sassari 07100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Leeuwen, Elisabeth M" sort="Van Leeuwen, Elisabeth M" uniqKey="Van Leeuwen E" first="Elisabeth M." last="Van Leeuwen">Elisabeth M. Van Leeuwen</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a50"><institution>Department of Internal Medicine, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative</institution>, 2518 AD Hague,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a50"><institution>Department of Internal Medicine, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative</institution>, 2518 AD Hague,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative</institution>, 2518 AD Hague,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vingerling, Johannes R" sort="Vingerling, Johannes R" uniqKey="Vingerling J" first="Johannes R." last="Vingerling">Johannes R. Vingerling</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Ophthalmology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ya Xing" sort="Wang, Ya Xing" uniqKey="Wang Y" first="Ya Xing" last="Wang">Ya Xing Wang</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University</institution>, Beijing 100044,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xu" sort="Wang, Xu" uniqKey="Wang X" first="Xu" last="Wang">Xu Wang</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tai Hui Boh, Eileen" sort="Tai Hui Boh, Eileen" uniqKey="Tai Hui Boh E" first="Eileen" last="Tai-Hui Boh">Eileen Tai-Hui Boh</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ikram, M Kamran" sort="Ikram, M Kamran" uniqKey="Ikram M" first="M. Kamran" last="Ikram">M. Kamran Ikram</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sabanayagam, Charumathi" sort="Sabanayagam, Charumathi" uniqKey="Sabanayagam C" first="Charumathi" last="Sabanayagam">Charumathi Sabanayagam</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gupta, Preeti" sort="Gupta, Preeti" uniqKey="Gupta P" first="Preeti" last="Gupta">Preeti Gupta</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Vincent" sort="Tan, Vincent" uniqKey="Tan V" first="Vincent" last="Tan">Vincent Tan</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Lei" sort="Zhou, Lei" uniqKey="Zhou L" first="Lei" last="Zhou">Lei Zhou</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Candice E H" sort="Ho, Candice E H" uniqKey="Ho C" first="Candice E. H." last="Ho">Candice E. H. Ho</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Wan E" sort="Lim, Wan E" uniqKey="Lim W" first="Wan'E" last="Lim">Wan'E Lim</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beuerman, Roger W" sort="Beuerman, Roger W" uniqKey="Beuerman R" first="Roger W." last="Beuerman">Roger W. Beuerman</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Siantar, Rosalynn" sort="Siantar, Rosalynn" uniqKey="Siantar R" first="Rosalynn" last="Siantar">Rosalynn Siantar</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a54"><institution>National Healthcare Group Eye Institute, Tan Tock Seng Hospital</institution>, Singapore 308433,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Department of Medicine, National University of Singapore</institution>, Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Estonian Genome Center, University of Tartu</institution>, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a56"><institution>Division of Human Genetics, Genome Institute of Singapore</institution>, Singapore 138672,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="a12"><institution>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0SR,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foster, Paul J" sort="Foster, Paul J" uniqKey="Foster P" first="Paul J." last="Foster">Paul J. Foster</name><affiliation wicri:level="1"><nlm:aff id="a57"><institution>Division of Genetics and Epidemiology, UCL Institute of Ophthalmology</institution>, London EC1V 9EL,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a58"><institution>NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology</institution>, London EC1V 2PD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Barbara E K" sort="Klein, Barbara E K" uniqKey="Klein B" first="Barbara E. K." last="Klein">Barbara E. K. Klein</name><affiliation wicri:level="1"><nlm:aff id="a59"><institution>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health</institution>, Madison, Wisconsin 53726,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Ronald" sort="Klein, Ronald" uniqKey="Klein R" first="Ronald" last="Klein">Ronald Klein</name><affiliation wicri:level="1"><nlm:aff id="a59"><institution>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health</institution>, Madison, Wisconsin 53726,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Hoi Suen" sort="Wong, Hoi Suen" uniqKey="Wong H" first="Hoi-Suen" last="Wong">Hoi-Suen Wong</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto</institution>, Toronto Ontario,<country>Canada</country> M5G 1X8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="1"><nlm:aff id="a60"><institution>Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney</institution>, Sydney, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Estonian Genome Center, University of Tartu</institution>, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L." last="Young">Terri L. Young</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin</institution>, Madison, Wisconsin 53705, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Madison, Wisconsin 53705</wicri:regionArea><wicri:noRegion>Wisconsin 53705</wicri:noRegion></affiliation></author><author><name sortKey="He, Mingguang" sort="He, Mingguang" uniqKey="He M" first="Mingguang" last="He">Mingguang He</name><affiliation wicri:level="1"><nlm:aff id="a62"><institution>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University</institution>, Guangzhou 510060,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="P Rssinen, Olavi" sort="P Rssinen, Olavi" uniqKey="P Rssinen O" first="Olavi" last="P Rssinen">Olavi P Rssinen</name><affiliation wicri:level="1"><nlm:aff id="a63"><institution>Department of Ophthalmology, Central Hospital of Central Finland</institution>, Jyväskylä 40620,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a64"><institution>Gerontology Research Center and Department of Health Sciences, University of Jyväskylä</institution>, Jyväskylä 40014,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jin Wang, Jie" sort="Jin Wang, Jie" uniqKey="Jin Wang J" first="Jie" last="Jin Wang">Jie Jin Wang</name><affiliation wicri:level="1"><nlm:aff id="a60"><institution>Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney</institution>, Sydney, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Williams, Cathy" sort="Williams, Cathy" uniqKey="Williams C" first="Cathy" last="Williams">Cathy Williams</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>School of Social and Community Medicine, University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B." last="Jonas">Jost B. Jonas</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University</institution>, Beijing 100044,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a65"><institution>Medical Faculty Mannheim, Department of Ophthalmology, Ruprecht-Karls-University Heidelberg</institution>, 69115 Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a56"><institution>Division of Human Genetics, Genome Institute of Singapore</institution>, Singapore 138672,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Department of Statistics and Applied Probability, National University of Singapore</institution>, Singapore 117546,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>, Hobart, Tasmania 7000,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a67"><institution>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia</institution>, Perth, Western Australia 6009,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oexle, Konrad" sort="Oexle, Konrad" uniqKey="Oexle K" first="Konrad" last="Oexle">Konrad Oexle</name><affiliation wicri:level="1"><nlm:aff id="a48"><institution>Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München</institution>, 81675 Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yoshimura, Nagahisa" sort="Yoshimura, Nagahisa" uniqKey="Yoshimura N" first="Nagahisa" last="Yoshimura">Nagahisa Yoshimura</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine</institution>, Kyoto 6068507,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paterson, Andrew D" sort="Paterson, Andrew D" uniqKey="Paterson A" first="Andrew D." last="Paterson">Andrew D. Paterson</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto</institution>, Toronto Ontario,<country>Canada</country> M5G 1X8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Ophthalmology, University Medical Center Mainz</institution>, 55131 Mainz,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baird, Paul N" sort="Baird, Paul N" uniqKey="Baird P" first="Paul N." last="Baird">Paul N. Baird</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne</institution>, Melbourne, Victoria 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stambolian, Dwight" sort="Stambolian, Dwight" uniqKey="Stambolian D" first="Dwight" last="Stambolian">Dwight Stambolian</name><affiliation wicri:level="1"><nlm:aff id="a68"><institution>Department of Ophthalmology, University of Pennsylvania</institution>, Philadelphia, Pennsylvania 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, Joan E Bailey" sort="Wilson, Joan E Bailey" uniqKey="Wilson J" first="Joan E. Bailey" last="Wilson">Joan E. Bailey Wilson</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health</institution>, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J." last="Hammond">Christopher J. Hammond</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Department of Ophthalmology, King's College London</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C. W." last="Klaver">Caroline C. W. Klaver</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Ophthalmology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rahi, Jugnoo S" sort="Rahi, Jugnoo S" uniqKey="Rahi J" first="Jugnoo S." last="Rahi">Jugnoo S. Rahi</name><affiliation wicri:level="4"><nlm:aff id="a69">Medical Research Council Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="a70">Institute of Ophthalmology, Moorfields Eye Hospital, London EC1V 2PD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Ophthalmology, Moorfields Eye Hospital, London EC1V 2PD</wicri:regionArea><wicri:noRegion>London EC1V 2PD</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="a71">Ulverscroft Vision Research Group, University College London, London WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ulverscroft Vision Research Group, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Korobelnik, Jean Francois" sort="Korobelnik, Jean Francois" uniqKey="Korobelnik J" first="Jean-François" last="Korobelnik">Jean-François Korobelnik</name><affiliation wicri:level="4"><nlm:aff id="a72">Université de Bordeaux, 33400 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, 33400 Talence</wicri:regionArea><wicri:noRegion>33400 Talence</wicri:noRegion><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="a73">INSERM (Institut National de la Santé Et de la Recherche Médicale), ISPED (Institut de Santé Publique d'épidémiologie et de Développement), Centre INSERM U897-Epidemiologie-Biostatistique, 33076 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM (Institut National de la Santé Et de la Recherche Médicale), ISPED (Institut de Santé Publique d'épidémiologie et de Développement), Centre INSERM U897-Epidemiologie-Biostatistique, 33076 Bordeaux</wicri:regionArea><wicri:noRegion>33076 Bordeaux</wicri:noRegion><wicri:noRegion>33076 Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name><affiliation wicri:level="1"><nlm:aff id="a74">MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><affiliation wicri:level="1"><nlm:aff id="a74">MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:aff id="a74">MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="a75">Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001</wicri:regionArea><wicri:noRegion>South Australia 5001</wicri:noRegion></affiliation></author><author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P." last="Burdon">Kathryn P. Burdon</name><affiliation wicri:level="1"><nlm:aff id="a75">Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001</wicri:regionArea><wicri:noRegion>South Australia 5001</wicri:noRegion></affiliation></author><author><name sortKey="Fogarty, Rhys D" sort="Fogarty, Rhys D" uniqKey="Fogarty R" first="Rhys D." last="Fogarty">Rhys D. Fogarty</name><affiliation wicri:level="1"><nlm:aff id="a75">Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001</wicri:regionArea><wicri:noRegion>South Australia 5001</wicri:noRegion></affiliation></author><author><name sortKey="Iyengar, Sudha K" sort="Iyengar, Sudha K" uniqKey="Iyengar S" first="Sudha K." last="Iyengar">Sudha K. Iyengar</name><affiliation wicri:level="1"><nlm:aff id="a76">Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a77">Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a78">Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation></author><author><name sortKey="Chew, Emily" sort="Chew, Emily" uniqKey="Chew E" first="Emily" last="Chew">Emily Chew</name><affiliation wicri:level="1"><nlm:aff id="a79">National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Janmahasatian, Sarayut" sort="Janmahasatian, Sarayut" uniqKey="Janmahasatian S" first="Sarayut" last="Janmahasatian">Sarayut Janmahasatian</name><affiliation wicri:level="1"><nlm:aff id="a76">Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="a80">Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029</wicri:regionArea><wicri:noRegion>Queensland 4029</wicri:noRegion></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston</institution>, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University</institution>, Beijing 100044,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schache, Maria" sort="Schache, Maria" uniqKey="Schache M" first="Maria" last="Schache">Maria Schache</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne</institution>, Melbourne, Victoria 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nangia, Vinay" sort="Nangia, Vinay" uniqKey="Nangia V" first="Vinay" last="Nangia">Vinay Nangia</name><affiliation wicri:level="1"><nlm:aff id="a81">Suraj Eye Institute, Nagpur, Maharashtra 440001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Suraj Eye Institute, Nagpur, Maharashtra 440001</wicri:regionArea><wicri:noRegion>Maharashtra 440001</wicri:noRegion></affiliation></author><author><name sortKey="Panda Jonas, Songhomitra" sort="Panda Jonas, Songhomitra" uniqKey="Panda Jonas S" first="Songhomitra" last="Panda-Jonas">Songhomitra Panda-Jonas</name><affiliation wicri:level="1"><nlm:aff id="a81">Suraj Eye Institute, Nagpur, Maharashtra 440001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Suraj Eye Institute, Nagpur, Maharashtra 440001</wicri:regionArea><wicri:noRegion>Maharashtra 440001</wicri:noRegion></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="a12"><institution>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Fondran, Jeremy R" sort="Fondran, Jeremy R" uniqKey="Fondran J" first="Jeremy R." last="Fondran">Jeremy R. Fondran</name><affiliation wicri:level="1"><nlm:aff id="a76">Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation></author><author><name sortKey="Lass, Jonathan H" sort="Lass, Jonathan H" uniqKey="Lass J" first="Jonathan H." last="Lass">Jonathan H. Lass</name><affiliation wicri:level="1"><nlm:aff id="a76">Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a77">Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Sheng" sort="Feng, Sheng" uniqKey="Feng S" first="Sheng" last="Feng">Sheng Feng</name><affiliation wicri:level="1"><nlm:aff id="a82">Department of Pediatric Ophthalmology, Duke Eye Center For Human Genetics, Durham, North Carolina 27710, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatric Ophthalmology, Duke Eye Center For Human Genetics, Durham, North Carolina 27710</wicri:regionArea><wicri:noRegion>North Carolina 27710</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation wicri:level="4"><nlm:aff id="a83">MRC Epidemiology Unit, Institute of Metabolic Sciences, University of Cambridge, Cambridge CB2 1TN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Sciences, University of Cambridge, Cambridge CB2 1TN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0SR,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J." last="Wareham">Nick J. Wareham</name><affiliation wicri:level="1"><nlm:aff id="a84">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Rantanen, Taina" sort="Rantanen, Taina" uniqKey="Rantanen T" first="Taina" last="Rantanen">Taina Rantanen</name><affiliation wicri:level="4"><nlm:aff id="a85">Gerontology Research Center, University of Jyväskylä, Jyväskylä Finland</nlm:aff><orgName type="university">Université de Jyväskylä</orgName><country>Finlande</country><placeName><settlement type="city">Jyväskylä</settlement><region type="région" nuts="2">Finlande-Centrale</region></placeName></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="4"><nlm:aff id="a86">Department of Public Health, University of Helsinki, Helsinki 00014, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Public Health, University of Helsinki, Helsinki 00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="a87">Institute for Molecular Medicine, University of Helsinki, Helsinki 00014, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine, University of Helsinki, Helsinki 00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="a88">Department of Mental Health and Alcohol Abuse Services, National Institute for Health and Welfare, Helsinki 00271, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Mental Health and Alcohol Abuse Services, National Institute for Health and Welfare, Helsinki 00271</wicri:regionArea><wicri:noRegion>Helsinki 00271</wicri:noRegion></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation wicri:level="4"><nlm:aff id="a89">Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li Jia" last="Chen">Li Jia Chen</name><affiliation wicri:level="4"><nlm:aff id="a90">Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Tam, Pancy O" sort="Tam, Pancy O" uniqKey="Tam P" first="Pancy O." last="Tam">Pancy O. Tam</name><affiliation wicri:level="4"><nlm:aff id="a89">Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Jhanji, Vishal" sort="Jhanji, Vishal" uniqKey="Jhanji V" first="Vishal" last="Jhanji">Vishal Jhanji</name><affiliation wicri:level="4"><nlm:aff id="a89">Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="a90">Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Young, Alvin L" sort="Young, Alvin L" uniqKey="Young A" first="Alvin L." last="Young">Alvin L. Young</name><affiliation wicri:level="4"><nlm:aff id="a89">Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="a90">Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation wicri:level="1"><nlm:aff id="a91">Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a92">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Raffel, Leslie J" sort="Raffel, Leslie J" uniqKey="Raffel L" first="Leslie J." last="Raffel">Leslie J. Raffel</name><affiliation wicri:level="1"><nlm:aff id="a93">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048</wicri:regionArea><wicri:noRegion>California 90048</wicri:noRegion></affiliation></author><author><name sortKey="Cotch, Mary Frances" sort="Cotch, Mary Frances" uniqKey="Cotch M" first="Mary-Frances" last="Cotch">Mary-Frances Cotch</name><affiliation wicri:level="1"><nlm:aff id="a94">Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiaohui" sort="Li, Xiaohui" uniqKey="Li X" first="Xiaohui" last="Li">Xiaohui Li</name><affiliation wicri:level="1"><nlm:aff id="a95">Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Los Angeles, California 90502, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Los Angeles, California 90502</wicri:regionArea><wicri:noRegion>California 90502</wicri:noRegion></affiliation></author><author><name sortKey="Yip, Shea Ping" sort="Yip, Shea Ping" uniqKey="Yip S" first="Shea Ping" last="Yip">Shea Ping Yip</name><affiliation wicri:level="1"><nlm:aff id="a96">Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yap, Maurice K H" sort="Yap, Maurice K H" uniqKey="Yap M" first="Maurice K. H." last="Yap">Maurice K. H. Yap</name><affiliation wicri:level="1"><nlm:aff id="a96">Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Biino, Ginevra" sort="Biino, Ginevra" uniqKey="Biino G" first="Ginevra" last="Biino">Ginevra Biino</name><affiliation wicri:level="1"><nlm:aff id="a97">Institute of Molecular Genetics, National Research Council, Pavia 27100, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Molecular Genetics, National Research Council, Pavia 27100</wicri:regionArea><wicri:noRegion>Pavia 27100</wicri:noRegion></affiliation></author><author><name sortKey="Vaccargiu, Simona" sort="Vaccargiu, Simona" uniqKey="Vaccargiu S" first="Simona" last="Vaccargiu">Simona Vaccargiu</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Institute of Population Genetics, National Research Council</institution>, Sassari 07100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fossarello, Maurizio" sort="Fossarello, Maurizio" uniqKey="Fossarello M" first="Maurizio" last="Fossarello">Maurizio Fossarello</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Institute of Population Genetics, National Research Council</institution>, Sassari 07100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fleck, Brian" sort="Fleck, Brian" uniqKey="Fleck B" first="Brian" last="Fleck">Brian Fleck</name><affiliation wicri:level="1"><nlm:aff id="a98">Princess Alexandra Eye Pavilion, Edinburgh EH3 9HA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Princess Alexandra Eye Pavilion, Edinburgh EH3 9HA</wicri:regionArea><wicri:noRegion>Edinburgh EH3 9HA</wicri:noRegion></affiliation></author><author><name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne</institution>, Melbourne, Victoria 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a67"><institution>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia</institution>, Perth, Western Australia 6009,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tideman, Jan Willem L" sort="Tideman, Jan Willem L" uniqKey="Tideman J" first="Jan Willem L." last="Tideman">Jan Willem L. Tideman</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Ophthalmology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tedja, Milly" sort="Tedja, Milly" uniqKey="Tedja M" first="Milly" last="Tedja">Milly Tedja</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Ophthalmology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deangelis, Margaret M" sort="Deangelis, Margaret M" uniqKey="Deangelis M" first="Margaret M." last="Deangelis">Margaret M. Deangelis</name><affiliation wicri:level="1"><nlm:aff id="a99">Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah 84132</wicri:regionArea><wicri:noRegion>Utah 84132</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Margaux" sort="Morrison, Margaux" uniqKey="Morrison M" first="Margaux" last="Morrison">Margaux Morrison</name><affiliation wicri:level="1"><nlm:aff id="a100">Department of Ophthalmology and Visual Sciences, John Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, John Moran Eye Center, University of Utah, Salt Lake City, Utah 84132</wicri:regionArea><wicri:noRegion>Utah 84132</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Lindsay" sort="Farrer, Lindsay" uniqKey="Farrer L" first="Lindsay" last="Farrer">Lindsay Farrer</name><affiliation wicri:level="1"><nlm:aff id="a101">Departments of Medicine (Biomedical Genetics), Ophthalmology, Neurology, Epidemiology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Medicine (Biomedical Genetics), Ophthalmology, Neurology, Epidemiology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts 02118</wicri:regionArea><wicri:noRegion>Massachusetts 02118</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Xiangtian" sort="Zhou, Xiangtian" uniqKey="Zhou X" first="Xiangtian" last="Zhou">Xiangtian Zhou</name><affiliation wicri:level="1"><nlm:aff id="a102">School of ophthalmology and optometry, Wenzhou Medical University, Wenzhou 325035, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of ophthalmology and optometry, Wenzhou Medical University, Wenzhou 325035</wicri:regionArea><wicri:noRegion>Wenzhou 325035</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name><affiliation wicri:level="1"><nlm:aff id="a102">School of ophthalmology and optometry, Wenzhou Medical University, Wenzhou 325035, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of ophthalmology and optometry, Wenzhou Medical University, Wenzhou 325035</wicri:regionArea><wicri:noRegion>Wenzhou 325035</wicri:noRegion></affiliation></author><author><name sortKey="Mizuki, Nobuhisa" sort="Mizuki, Nobuhisa" uniqKey="Mizuki N" first="Nobuhisa" last="Mizuki">Nobuhisa Mizuki</name><affiliation wicri:level="1"><nlm:aff id="a103">Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027</wicri:regionArea><wicri:noRegion>Kanagawa 236-0027</wicri:noRegion></affiliation></author><author><name sortKey="Meguro, Akira" sort="Meguro, Akira" uniqKey="Meguro A" first="Akira" last="Meguro">Akira Meguro</name><affiliation wicri:level="1"><nlm:aff id="a103">Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027</wicri:regionArea><wicri:noRegion>Kanagawa 236-0027</wicri:noRegion></affiliation></author><author><name sortKey="M Kel, Kari Matti" sort="M Kel, Kari Matti" uniqKey="M Kel K" first="Kari Matti" last="M Kel">Kari Matti M Kel</name><affiliation wicri:level="1"><nlm:aff id="a104">Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere 33014, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere 33014</wicri:regionArea><wicri:noRegion>Tampere 33014</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27020472</idno><idno type="pmc">4820539</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820539</idno><idno type="RBID">PMC:4820539</idno><idno type="doi">10.1038/ncomms11008</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000764</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000764</idno><idno type="wicri:Area/Pmc/Curation">000763</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000763</idno><idno type="wicri:Area/Pmc/Checkpoint">000779</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000779</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002101</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002101</idno><idno type="wicri:Area/PubMed/Curation">002076</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002076</idno><idno type="wicri:Area/PubMed/Checkpoint">002076</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002076</idno><idno type="wicri:Area/Ncbi/Merge">003334</idno><idno type="wicri:Area/Ncbi/Curation">003334</idno><idno type="wicri:Area/Ncbi/Checkpoint">003334</idno><idno type="wicri:Area/Main/Merge">001B20</idno><idno type="wicri:Area/Main/Curation">001B24</idno><idno type="wicri:Area/Main/Exploration">001B24</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error</title><author><name sortKey="Fan, Qiao" sort="Fan, Qiao" uniqKey="Fan Q" first="Qiao" last="Fan">Qiao Fan</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Verhoeven, Virginie J M" sort="Verhoeven, Virginie J M" uniqKey="Verhoeven V" first="Virginie J. M." last="Verhoeven">Virginie J. M. Verhoeven</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Ophthalmology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wojciechowski, Robert" sort="Wojciechowski, Robert" uniqKey="Wojciechowski R" first="Robert" last="Wojciechowski">Robert Wojciechowski</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health</institution>, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health</institution>, Baltimore, Maryland 20205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barathi, Veluchamy A" sort="Barathi, Veluchamy A" uniqKey="Barathi V" first="Veluchamy A." last="Barathi">Veluchamy A. Barathi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guggenheim, Jeremy A" sort="Guggenheim, Jeremy A" uniqKey="Guggenheim J" first="Jeremy A." last="Guggenheim">Jeremy A. Guggenheim</name><affiliation wicri:level="1"><nlm:aff id="a9"><institution>School of Optometry and Vision Sciences, Cardiff University</institution>, Cardiff CF24 4HQ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hohn, Rene" sort="Hohn, Rene" uniqKey="Hohn R" first="René" last="Höhn">René Höhn</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Ophthalmology, University Medical Center Mainz</institution>, 55131 Mainz,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Department of Ophthalmology, Inselspital, University Hospital Bern</institution>, CH-3010 Bern,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="a12"><institution>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Khawaja, Anthony P" sort="Khawaja, Anthony P" uniqKey="Khawaja A" first="Anthony P." last="Khawaja">Anthony P. Khawaja</name><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0SR,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yamashiro, Kenji" sort="Yamashiro, Kenji" uniqKey="Yamashiro K" first="Kenji" last="Yamashiro">Kenji Yamashiro</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine</institution>, Kyoto 6068507,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hosseini, S Mohsen" sort="Hosseini, S Mohsen" uniqKey="Hosseini S" first="S Mohsen" last="Hosseini">S Mohsen Hosseini</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto</institution>, Toronto Ontario,<country>Canada</country> M5G 1X8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere</institution>, Tampere 33520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Yi" sort="Lu, Yi" uniqKey="Lu Y" first="Yi" last="Lu">Yi Lu</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston</institution>, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haller, Toomas" sort="Haller, Toomas" uniqKey="Haller T" first="Toomas" last="Haller">Toomas Haller</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Estonian Genome Center, University of Tartu</institution>, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne</institution>, Melbourne, Victoria 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Delcourt, Cecile" sort="Delcourt, Cecile" uniqKey="Delcourt C" first="Cécile" last="Delcourt">Cécile Delcourt</name><affiliation wicri:level="1"><nlm:aff id="a20"><institution>Université de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement)</institution>, Bordeaux 33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a21"><institution>INSERM, U1219-Bordeaux Population Health Research Center</institution>, Bordeaux 33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Institute of Population Genetics, National Research Council</institution>, Sassari 07100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wedenoja, Juho" sort="Wedenoja, Juho" uniqKey="Wedenoja J" first="Juho" last="Wedenoja">Juho Wedenoja</name><affiliation wicri:level="1"><nlm:aff id="a23"><institution>Department of Public Health, University of Helsinki</institution>, Helsinki 00014,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a24"><institution>Department of Ophthalmology, University of Helsinki and Helsinki University Hospital</institution>, Helsinki 00014,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston</institution>, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a25"><institution>UCL Institute of Ophthalmology</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miyake, Masahiro" sort="Miyake, Masahiro" uniqKey="Miyake M" first="Masahiro" last="Miyake">Masahiro Miyake</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine</institution>, Kyoto 6068507,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne</institution>, Melbourne, Victoria 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>, Hobart, Tasmania 7000,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guo, Xiaobo" sort="Guo, Xiaobo" uniqKey="Guo X" first="Xiaobo" last="Guo">Xiaobo Guo</name><affiliation wicri:level="1"><nlm:aff id="a27"><institution>Department of Statistical Science, School of Mathematics and Computational Science, Sun Yat-Sen University</institution>, Guangzhou 510275,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mazur, Johanna" sort="Mazur, Johanna" uniqKey="Mazur J" first="Johanna" last="Mazur">Johanna Mazur</name><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz</institution>, 55131 Mainz,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huffman, Jenifer E" sort="Huffman, Jenifer E" uniqKey="Huffman J" first="Jenifer E." last="Huffman">Jenifer E. Huffman</name><affiliation><nlm:aff id="a12"><institution>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Williams, Katie M" sort="Williams, Katie M" uniqKey="Williams K" first="Katie M." last="Williams">Katie M. Williams</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Department of Ophthalmology, King's College London</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation wicri:level="1"><nlm:aff id="a30"><institution>Faculty of Medicine, University of Split</institution>, Split 21000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="a31"><institution>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh</institution>, Teviot Place, Edinburgh EH8 9AG,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="a31"><institution>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh</institution>, Teviot Place, Edinburgh EH8 9AG,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Vatavuk, Zoran" sort="Vatavuk, Zoran" uniqKey="Vatavuk Z" first="Zoran" last="Vatavuk">Zoran Vatavuk</name><affiliation wicri:level="1"><nlm:aff id="a32"><institution>Department of Ophthalmology, Sisters of Mercy University Hospital</institution>, Zagreb 10000,<country>Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="a31"><institution>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh</institution>, Teviot Place, Edinburgh EH8 9AG,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation><nlm:aff id="a31"><institution>Usher Institute for Population Health Sciences and Informatics, University of Edinburgh</institution>, Teviot Place, Edinburgh EH8 9AG,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name><affiliation wicri:level="1"><nlm:aff id="a33"><institution>MRC Integrative Epidemiology Unit (IEU), University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a34"><institution>School of Social and Community Medicine, University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="St Pourcain, Beate" sort="St Pourcain, Beate" uniqKey="St Pourcain B" first="Beate" last="St Pourcain">Beate St Pourcain</name><affiliation wicri:level="1"><nlm:aff id="a33"><institution>MRC Integrative Epidemiology Unit (IEU), University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a34"><institution>School of Social and Community Medicine, University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a35"><institution>Max Planck Institute for Psycholinguistics</institution>, Wundtlaan 1, 6525 XD Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation wicri:level="1"><nlm:aff id="a33"><institution>MRC Integrative Epidemiology Unit (IEU), University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a34"><institution>School of Social and Community Medicine, University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a36"><institution>University of Queensland Diamantina Institute, Translational Research Institute</institution>, Brisbane, Queensland 4102,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simpson, Claire L" sort="Simpson, Claire L" uniqKey="Simpson C" first="Claire L." last="Simpson">Claire L. Simpson</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health</institution>, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a37"><institution>Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center</institution>, Memphis, Tennessee 38163,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schwantes An, Tae Hwi" sort="Schwantes An, Tae Hwi" uniqKey="Schwantes An T" first="Tae-Hwi" last="Schwantes-An">Tae-Hwi Schwantes-An</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health</institution>, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Igo, Robert P" sort="Igo, Robert P" uniqKey="Igo R" first="Robert P." last="Igo">Robert P. Igo</name><affiliation wicri:level="1"><nlm:aff id="a38"><institution>Department of Epidemiology and Biostatistics, Case Western Reserve University</institution>, Cleveland, Ohio 44106,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mirshahi, Alireza" sort="Mirshahi, Alireza" uniqKey="Mirshahi A" first="Alireza" last="Mirshahi">Alireza Mirshahi</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Ophthalmology, University Medical Center Mainz</institution>, 55131 Mainz,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a39"><institution>Dardenne Eye Hospital, Bonn-Bad Godesberg</institution>, 53177 Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cougnard Gregoire, Audrey" sort="Cougnard Gregoire, Audrey" uniqKey="Cougnard Gregoire A" first="Audrey" last="Cougnard-Gregoire">Audrey Cougnard-Gregoire</name><affiliation wicri:level="1"><nlm:aff id="a20"><institution>Université de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement)</institution>, Bordeaux 33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a21"><institution>INSERM, U1219-Bordeaux Population Health Research Center</institution>, Bordeaux 33000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation wicri:level="1"><nlm:aff id="a40"><institution>Inserm, U1167</institution>, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a41"><institution>Univ. Lille, U1167</institution>, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a42"><institution>Université Lille 2</institution>, Lille 59000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blettner, Maria" sort="Blettner, Maria" uniqKey="Blettner M" first="Maria" last="Blettner">Maria Blettner</name><affiliation wicri:level="1"><nlm:aff id="a28"><institution>Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz</institution>, 55131 Mainz,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="a43"><institution>Research Centre of Applied and Preventive Medicine, University of Turku</institution>, Turku 20520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a44"><institution>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital</institution>, Turku 20520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="a45"><institution>Department of Clinical Physiology, Tampere University Hospital and School of Medicine, University of Tampere</institution>, Tampere 33520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seppala, Ilkka" sort="Seppala, Ilkka" uniqKey="Seppala I" first="Ilkka" last="Seppala">Ilkka Seppala</name><affiliation wicri:level="1"><nlm:aff id="a16"><institution>Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere</institution>, Tampere 33520,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation wicri:level="1"><nlm:aff id="a46"><institution>Clinic for General and Interventional Cardiology, University Heart Center Hamburg</institution>, 20246 Hamburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><affiliation wicri:level="1"><nlm:aff id="a47"><institution>Institute of Human Genetics, Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a48"><institution>Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München</institution>, 81675 Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S." last="Ried">Janina S. Ried</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="a49"><institution>Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health</institution>, 85764 Neuherberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Institute of Population Genetics, National Research Council</institution>, Sassari 07100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Leeuwen, Elisabeth M" sort="Van Leeuwen, Elisabeth M" uniqKey="Van Leeuwen E" first="Elisabeth M." last="Van Leeuwen">Elisabeth M. Van Leeuwen</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a50"><institution>Department of Internal Medicine, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative</institution>, 2518 AD Hague,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a50"><institution>Department of Internal Medicine, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative</institution>, 2518 AD Hague,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a51"><institution>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative</institution>, 2518 AD Hague,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vingerling, Johannes R" sort="Vingerling, Johannes R" uniqKey="Vingerling J" first="Johannes R." last="Vingerling">Johannes R. Vingerling</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Ophthalmology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ya Xing" sort="Wang, Ya Xing" uniqKey="Wang Y" first="Ya Xing" last="Wang">Ya Xing Wang</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University</institution>, Beijing 100044,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xu" sort="Wang, Xu" uniqKey="Wang X" first="Xu" last="Wang">Xu Wang</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tai Hui Boh, Eileen" sort="Tai Hui Boh, Eileen" uniqKey="Tai Hui Boh E" first="Eileen" last="Tai-Hui Boh">Eileen Tai-Hui Boh</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ikram, M Kamran" sort="Ikram, M Kamran" uniqKey="Ikram M" first="M. Kamran" last="Ikram">M. Kamran Ikram</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sabanayagam, Charumathi" sort="Sabanayagam, Charumathi" uniqKey="Sabanayagam C" first="Charumathi" last="Sabanayagam">Charumathi Sabanayagam</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gupta, Preeti" sort="Gupta, Preeti" uniqKey="Gupta P" first="Preeti" last="Gupta">Preeti Gupta</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Vincent" sort="Tan, Vincent" uniqKey="Tan V" first="Vincent" last="Tan">Vincent Tan</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Lei" sort="Zhou, Lei" uniqKey="Zhou L" first="Lei" last="Zhou">Lei Zhou</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Candice E H" sort="Ho, Candice E H" uniqKey="Ho C" first="Candice E. H." last="Ho">Candice E. H. Ho</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Wan E" sort="Lim, Wan E" uniqKey="Lim W" first="Wan'E" last="Lim">Wan'E Lim</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beuerman, Roger W" sort="Beuerman, Roger W" uniqKey="Beuerman R" first="Roger W." last="Beuerman">Roger W. Beuerman</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Siantar, Rosalynn" sort="Siantar, Rosalynn" uniqKey="Siantar R" first="Rosalynn" last="Siantar">Rosalynn Siantar</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a54"><institution>National Healthcare Group Eye Institute, Tan Tock Seng Hospital</institution>, Singapore 308433,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a55"><institution>Department of Medicine, National University of Singapore</institution>, Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Estonian Genome Center, University of Tartu</institution>, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a56"><institution>Division of Human Genetics, Genome Institute of Singapore</institution>, Singapore 138672,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="a12"><institution>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0SR,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foster, Paul J" sort="Foster, Paul J" uniqKey="Foster P" first="Paul J." last="Foster">Paul J. Foster</name><affiliation wicri:level="1"><nlm:aff id="a57"><institution>Division of Genetics and Epidemiology, UCL Institute of Ophthalmology</institution>, London EC1V 9EL,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a58"><institution>NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology</institution>, London EC1V 2PD,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Barbara E K" sort="Klein, Barbara E K" uniqKey="Klein B" first="Barbara E. K." last="Klein">Barbara E. K. Klein</name><affiliation wicri:level="1"><nlm:aff id="a59"><institution>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health</institution>, Madison, Wisconsin 53726,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Ronald" sort="Klein, Ronald" uniqKey="Klein R" first="Ronald" last="Klein">Ronald Klein</name><affiliation wicri:level="1"><nlm:aff id="a59"><institution>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health</institution>, Madison, Wisconsin 53726,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Hoi Suen" sort="Wong, Hoi Suen" uniqKey="Wong H" first="Hoi-Suen" last="Wong">Hoi-Suen Wong</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto</institution>, Toronto Ontario,<country>Canada</country> M5G 1X8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="1"><nlm:aff id="a60"><institution>Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney</institution>, Sydney, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="a18"><institution>Estonian Genome Center, University of Tartu</institution>, Tartu 51010,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L." last="Young">Terri L. Young</name><affiliation wicri:level="1"><nlm:aff id="a61"><institution>Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin</institution>, Madison, Wisconsin 53705, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Madison, Wisconsin 53705</wicri:regionArea><wicri:noRegion>Wisconsin 53705</wicri:noRegion></affiliation></author><author><name sortKey="He, Mingguang" sort="He, Mingguang" uniqKey="He M" first="Mingguang" last="He">Mingguang He</name><affiliation wicri:level="1"><nlm:aff id="a62"><institution>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University</institution>, Guangzhou 510060,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="P Rssinen, Olavi" sort="P Rssinen, Olavi" uniqKey="P Rssinen O" first="Olavi" last="P Rssinen">Olavi P Rssinen</name><affiliation wicri:level="1"><nlm:aff id="a63"><institution>Department of Ophthalmology, Central Hospital of Central Finland</institution>, Jyväskylä 40620,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a64"><institution>Gerontology Research Center and Department of Health Sciences, University of Jyväskylä</institution>, Jyväskylä 40014,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jin Wang, Jie" sort="Jin Wang, Jie" uniqKey="Jin Wang J" first="Jie" last="Jin Wang">Jie Jin Wang</name><affiliation wicri:level="1"><nlm:aff id="a60"><institution>Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney</institution>, Sydney, New South Wales 2145,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Williams, Cathy" sort="Williams, Cathy" uniqKey="Williams C" first="Cathy" last="Williams">Cathy Williams</name><affiliation wicri:level="1"><nlm:aff id="a34"><institution>School of Social and Community Medicine, University of Bristol</institution>, Bristol BS8 2BN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B." last="Jonas">Jost B. Jonas</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University</institution>, Beijing 100044,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a65"><institution>Medical Faculty Mannheim, Department of Ophthalmology, Ruprecht-Karls-University Heidelberg</institution>, 69115 Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a56"><institution>Division of Human Genetics, Genome Institute of Singapore</institution>, Singapore 138672,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a66"><institution>Department of Statistics and Applied Probability, National University of Singapore</institution>, Singapore 117546,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:aff id="a26"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>, Hobart, Tasmania 7000,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a67"><institution>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia</institution>, Perth, Western Australia 6009,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oexle, Konrad" sort="Oexle, Konrad" uniqKey="Oexle K" first="Konrad" last="Oexle">Konrad Oexle</name><affiliation wicri:level="1"><nlm:aff id="a48"><institution>Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München</institution>, 81675 Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yoshimura, Nagahisa" sort="Yoshimura, Nagahisa" uniqKey="Yoshimura N" first="Nagahisa" last="Yoshimura">Nagahisa Yoshimura</name><affiliation wicri:level="1"><nlm:aff id="a14"><institution>Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine</institution>, Kyoto 6068507,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paterson, Andrew D" sort="Paterson, Andrew D" uniqKey="Paterson A" first="Andrew D." last="Paterson">Andrew D. Paterson</name><affiliation wicri:level="1"><nlm:aff id="a15"><institution>Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto</institution>, Toronto Ontario,<country>Canada</country> M5G 1X8</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Ophthalmology, University Medical Center Mainz</institution>, 55131 Mainz,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baird, Paul N" sort="Baird, Paul N" uniqKey="Baird P" first="Paul N." last="Baird">Paul N. Baird</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne</institution>, Melbourne, Victoria 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stambolian, Dwight" sort="Stambolian, Dwight" uniqKey="Stambolian D" first="Dwight" last="Stambolian">Dwight Stambolian</name><affiliation wicri:level="1"><nlm:aff id="a68"><institution>Department of Ophthalmology, University of Pennsylvania</institution>, Philadelphia, Pennsylvania 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, Joan E Bailey" sort="Wilson, Joan E Bailey" uniqKey="Wilson J" first="Joan E. Bailey" last="Wilson">Joan E. Bailey Wilson</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health</institution>, Baltimore, Maryland 21224,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J." last="Hammond">Christopher J. Hammond</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a29"><institution>Department of Ophthalmology, King's College London</institution>, London SE1 7EH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C. W." last="Klaver">Caroline C. W. Klaver</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Ophthalmology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Singapore Eye Research Institute, Singapore National Eye Centre</institution>, Singapore 169856,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Duke-NUS Medical School</institution>, Singapore 169857,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Department of Ophthalmology, National University Health Systems, National University of Singapore</institution> Singapore 119228,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a53"><institution>Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems</institution>, Singapore 117549,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rahi, Jugnoo S" sort="Rahi, Jugnoo S" uniqKey="Rahi J" first="Jugnoo S." last="Rahi">Jugnoo S. Rahi</name><affiliation wicri:level="4"><nlm:aff id="a69">Medical Research Council Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="a70">Institute of Ophthalmology, Moorfields Eye Hospital, London EC1V 2PD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Ophthalmology, Moorfields Eye Hospital, London EC1V 2PD</wicri:regionArea><wicri:noRegion>London EC1V 2PD</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="a71">Ulverscroft Vision Research Group, University College London, London WC1E 6BT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ulverscroft Vision Research Group, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Korobelnik, Jean Francois" sort="Korobelnik, Jean Francois" uniqKey="Korobelnik J" first="Jean-François" last="Korobelnik">Jean-François Korobelnik</name><affiliation wicri:level="4"><nlm:aff id="a72">Université de Bordeaux, 33400 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, 33400 Talence</wicri:regionArea><wicri:noRegion>33400 Talence</wicri:noRegion><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="a73">INSERM (Institut National de la Santé Et de la Recherche Médicale), ISPED (Institut de Santé Publique d'épidémiologie et de Développement), Centre INSERM U897-Epidemiologie-Biostatistique, 33076 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM (Institut National de la Santé Et de la Recherche Médicale), ISPED (Institut de Santé Publique d'épidémiologie et de Développement), Centre INSERM U897-Epidemiologie-Biostatistique, 33076 Bordeaux</wicri:regionArea><wicri:noRegion>33076 Bordeaux</wicri:noRegion><wicri:noRegion>33076 Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name><affiliation wicri:level="1"><nlm:aff id="a74">MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><affiliation wicri:level="1"><nlm:aff id="a74">MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:aff id="a74">MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="a75">Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001</wicri:regionArea><wicri:noRegion>South Australia 5001</wicri:noRegion></affiliation></author><author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P." last="Burdon">Kathryn P. Burdon</name><affiliation wicri:level="1"><nlm:aff id="a75">Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001</wicri:regionArea><wicri:noRegion>South Australia 5001</wicri:noRegion></affiliation></author><author><name sortKey="Fogarty, Rhys D" sort="Fogarty, Rhys D" uniqKey="Fogarty R" first="Rhys D." last="Fogarty">Rhys D. Fogarty</name><affiliation wicri:level="1"><nlm:aff id="a75">Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide, South Australia 5001</wicri:regionArea><wicri:noRegion>South Australia 5001</wicri:noRegion></affiliation></author><author><name sortKey="Iyengar, Sudha K" sort="Iyengar, Sudha K" uniqKey="Iyengar S" first="Sudha K." last="Iyengar">Sudha K. Iyengar</name><affiliation wicri:level="1"><nlm:aff id="a76">Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a77">Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a78">Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation></author><author><name sortKey="Chew, Emily" sort="Chew, Emily" uniqKey="Chew E" first="Emily" last="Chew">Emily Chew</name><affiliation wicri:level="1"><nlm:aff id="a79">National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Janmahasatian, Sarayut" sort="Janmahasatian, Sarayut" uniqKey="Janmahasatian S" first="Sarayut" last="Janmahasatian">Sarayut Janmahasatian</name><affiliation wicri:level="1"><nlm:aff id="a76">Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="a80">Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029</wicri:regionArea><wicri:noRegion>Queensland 4029</wicri:noRegion></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:aff id="a17"><institution>Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston</institution>, Brisbane, Queensland 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name><affiliation wicri:level="1"><nlm:aff id="a52"><institution>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University</institution>, Beijing 100044,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schache, Maria" sort="Schache, Maria" uniqKey="Schache M" first="Maria" last="Schache">Maria Schache</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne</institution>, Melbourne, Victoria 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nangia, Vinay" sort="Nangia, Vinay" uniqKey="Nangia V" first="Vinay" last="Nangia">Vinay Nangia</name><affiliation wicri:level="1"><nlm:aff id="a81">Suraj Eye Institute, Nagpur, Maharashtra 440001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Suraj Eye Institute, Nagpur, Maharashtra 440001</wicri:regionArea><wicri:noRegion>Maharashtra 440001</wicri:noRegion></affiliation></author><author><name sortKey="Panda Jonas, Songhomitra" sort="Panda Jonas, Songhomitra" uniqKey="Panda Jonas S" first="Songhomitra" last="Panda-Jonas">Songhomitra Panda-Jonas</name><affiliation wicri:level="1"><nlm:aff id="a81">Suraj Eye Institute, Nagpur, Maharashtra 440001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Suraj Eye Institute, Nagpur, Maharashtra 440001</wicri:regionArea><wicri:noRegion>Maharashtra 440001</wicri:noRegion></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="a12"><institution>Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>Scotland</country></nlm:aff><wicri:noCountry code="nlm country">Scotland</wicri:noCountry></affiliation></author><author><name sortKey="Fondran, Jeremy R" sort="Fondran, Jeremy R" uniqKey="Fondran J" first="Jeremy R." last="Fondran">Jeremy R. Fondran</name><affiliation wicri:level="1"><nlm:aff id="a76">Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation></author><author><name sortKey="Lass, Jonathan H" sort="Lass, Jonathan H" uniqKey="Lass J" first="Jonathan H." last="Lass">Jonathan H. Lass</name><affiliation wicri:level="1"><nlm:aff id="a76">Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, CaseWestern Reserve University, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a77">Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio 44106, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio 44106</wicri:regionArea><wicri:noRegion>Ohio 44106</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Sheng" sort="Feng, Sheng" uniqKey="Feng S" first="Sheng" last="Feng">Sheng Feng</name><affiliation wicri:level="1"><nlm:aff id="a82">Department of Pediatric Ophthalmology, Duke Eye Center For Human Genetics, Durham, North Carolina 27710, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatric Ophthalmology, Duke Eye Center For Human Genetics, Durham, North Carolina 27710</wicri:regionArea><wicri:noRegion>North Carolina 27710</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation wicri:level="4"><nlm:aff id="a83">MRC Epidemiology Unit, Institute of Metabolic Sciences, University of Cambridge, Cambridge CB2 1TN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Sciences, University of Cambridge, Cambridge CB2 1TN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="a13"><institution>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0SR,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J." last="Wareham">Nick J. Wareham</name><affiliation wicri:level="1"><nlm:aff id="a84">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Rantanen, Taina" sort="Rantanen, Taina" uniqKey="Rantanen T" first="Taina" last="Rantanen">Taina Rantanen</name><affiliation wicri:level="4"><nlm:aff id="a85">Gerontology Research Center, University of Jyväskylä, Jyväskylä Finland</nlm:aff><orgName type="university">Université de Jyväskylä</orgName><country>Finlande</country><placeName><settlement type="city">Jyväskylä</settlement><region type="région" nuts="2">Finlande-Centrale</region></placeName></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="4"><nlm:aff id="a86">Department of Public Health, University of Helsinki, Helsinki 00014, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Public Health, University of Helsinki, Helsinki 00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="a87">Institute for Molecular Medicine, University of Helsinki, Helsinki 00014, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine, University of Helsinki, Helsinki 00014</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="a88">Department of Mental Health and Alcohol Abuse Services, National Institute for Health and Welfare, Helsinki 00271, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Mental Health and Alcohol Abuse Services, National Institute for Health and Welfare, Helsinki 00271</wicri:regionArea><wicri:noRegion>Helsinki 00271</wicri:noRegion></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation wicri:level="4"><nlm:aff id="a89">Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li Jia" last="Chen">Li Jia Chen</name><affiliation wicri:level="4"><nlm:aff id="a90">Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Tam, Pancy O" sort="Tam, Pancy O" uniqKey="Tam P" first="Pancy O." last="Tam">Pancy O. Tam</name><affiliation wicri:level="4"><nlm:aff id="a89">Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Jhanji, Vishal" sort="Jhanji, Vishal" uniqKey="Jhanji V" first="Vishal" last="Jhanji">Vishal Jhanji</name><affiliation wicri:level="4"><nlm:aff id="a89">Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="a90">Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Young, Alvin L" sort="Young, Alvin L" uniqKey="Young A" first="Alvin L." last="Young">Alvin L. Young</name><affiliation wicri:level="4"><nlm:aff id="a89">Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Kowloon</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="a90">Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation wicri:level="1"><nlm:aff id="a91">Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a92">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Raffel, Leslie J" sort="Raffel, Leslie J" uniqKey="Raffel L" first="Leslie J." last="Raffel">Leslie J. Raffel</name><affiliation wicri:level="1"><nlm:aff id="a93">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048</wicri:regionArea><wicri:noRegion>California 90048</wicri:noRegion></affiliation></author><author><name sortKey="Cotch, Mary Frances" sort="Cotch, Mary Frances" uniqKey="Cotch M" first="Mary-Frances" last="Cotch">Mary-Frances Cotch</name><affiliation wicri:level="1"><nlm:aff id="a94">Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiaohui" sort="Li, Xiaohui" uniqKey="Li X" first="Xiaohui" last="Li">Xiaohui Li</name><affiliation wicri:level="1"><nlm:aff id="a95">Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Los Angeles, California 90502, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Los Angeles, California 90502</wicri:regionArea><wicri:noRegion>California 90502</wicri:noRegion></affiliation></author><author><name sortKey="Yip, Shea Ping" sort="Yip, Shea Ping" uniqKey="Yip S" first="Shea Ping" last="Yip">Shea Ping Yip</name><affiliation wicri:level="1"><nlm:aff id="a96">Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yap, Maurice K H" sort="Yap, Maurice K H" uniqKey="Yap M" first="Maurice K. H." last="Yap">Maurice K. H. Yap</name><affiliation wicri:level="1"><nlm:aff id="a96">Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Biino, Ginevra" sort="Biino, Ginevra" uniqKey="Biino G" first="Ginevra" last="Biino">Ginevra Biino</name><affiliation wicri:level="1"><nlm:aff id="a97">Institute of Molecular Genetics, National Research Council, Pavia 27100, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Molecular Genetics, National Research Council, Pavia 27100</wicri:regionArea><wicri:noRegion>Pavia 27100</wicri:noRegion></affiliation></author><author><name sortKey="Vaccargiu, Simona" sort="Vaccargiu, Simona" uniqKey="Vaccargiu S" first="Simona" last="Vaccargiu">Simona Vaccargiu</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Institute of Population Genetics, National Research Council</institution>, Sassari 07100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fossarello, Maurizio" sort="Fossarello, Maurizio" uniqKey="Fossarello M" first="Maurizio" last="Fossarello">Maurizio Fossarello</name><affiliation wicri:level="1"><nlm:aff id="a22"><institution>Institute of Population Genetics, National Research Council</institution>, Sassari 07100,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fleck, Brian" sort="Fleck, Brian" uniqKey="Fleck B" first="Brian" last="Fleck">Brian Fleck</name><affiliation wicri:level="1"><nlm:aff id="a98">Princess Alexandra Eye Pavilion, Edinburgh EH3 9HA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Princess Alexandra Eye Pavilion, Edinburgh EH3 9HA</wicri:regionArea><wicri:noRegion>Edinburgh EH3 9HA</wicri:noRegion></affiliation></author><author><name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name><affiliation wicri:level="1"><nlm:aff id="a19"><institution>Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne</institution>, Melbourne, Victoria 3002,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a67"><institution>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia</institution>, Perth, Western Australia 6009,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tideman, Jan Willem L" sort="Tideman, Jan Willem L" uniqKey="Tideman J" first="Jan Willem L." last="Tideman">Jan Willem L. Tideman</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Ophthalmology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tedja, Milly" sort="Tedja, Milly" uniqKey="Tedja M" first="Milly" last="Tedja">Milly Tedja</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Ophthalmology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Epidemiology, Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deangelis, Margaret M" sort="Deangelis, Margaret M" uniqKey="Deangelis M" first="Margaret M." last="Deangelis">Margaret M. Deangelis</name><affiliation wicri:level="1"><nlm:aff id="a99">Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah 84132</wicri:regionArea><wicri:noRegion>Utah 84132</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Margaux" sort="Morrison, Margaux" uniqKey="Morrison M" first="Margaux" last="Morrison">Margaux Morrison</name><affiliation wicri:level="1"><nlm:aff id="a100">Department of Ophthalmology and Visual Sciences, John Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, John Moran Eye Center, University of Utah, Salt Lake City, Utah 84132</wicri:regionArea><wicri:noRegion>Utah 84132</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Lindsay" sort="Farrer, Lindsay" uniqKey="Farrer L" first="Lindsay" last="Farrer">Lindsay Farrer</name><affiliation wicri:level="1"><nlm:aff id="a101">Departments of Medicine (Biomedical Genetics), Ophthalmology, Neurology, Epidemiology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Medicine (Biomedical Genetics), Ophthalmology, Neurology, Epidemiology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts 02118</wicri:regionArea><wicri:noRegion>Massachusetts 02118</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Xiangtian" sort="Zhou, Xiangtian" uniqKey="Zhou X" first="Xiangtian" last="Zhou">Xiangtian Zhou</name><affiliation wicri:level="1"><nlm:aff id="a102">School of ophthalmology and optometry, Wenzhou Medical University, Wenzhou 325035, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of ophthalmology and optometry, Wenzhou Medical University, Wenzhou 325035</wicri:regionArea><wicri:noRegion>Wenzhou 325035</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name><affiliation wicri:level="1"><nlm:aff id="a102">School of ophthalmology and optometry, Wenzhou Medical University, Wenzhou 325035, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of ophthalmology and optometry, Wenzhou Medical University, Wenzhou 325035</wicri:regionArea><wicri:noRegion>Wenzhou 325035</wicri:noRegion></affiliation></author><author><name sortKey="Mizuki, Nobuhisa" sort="Mizuki, Nobuhisa" uniqKey="Mizuki N" first="Nobuhisa" last="Mizuki">Nobuhisa Mizuki</name><affiliation wicri:level="1"><nlm:aff id="a103">Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027</wicri:regionArea><wicri:noRegion>Kanagawa 236-0027</wicri:noRegion></affiliation></author><author><name sortKey="Meguro, Akira" sort="Meguro, Akira" uniqKey="Meguro A" first="Akira" last="Meguro">Akira Meguro</name><affiliation wicri:level="1"><nlm:aff id="a103">Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027</wicri:regionArea><wicri:noRegion>Kanagawa 236-0027</wicri:noRegion></affiliation></author><author><name sortKey="M Kel, Kari Matti" sort="M Kel, Kari Matti" uniqKey="M Kel K" first="Kari Matti" last="M Kel">Kari Matti M Kel</name><affiliation wicri:level="1"><nlm:aff id="a104">Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere 33014, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere 33014</wicri:regionArea><wicri:noRegion>Tampere 33014</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asian Continental Ancestry Group (genetics)</term><term>Educational Status</term><term>Environment</term><term>European Continental Ancestry Group (genetics)</term><term>Gene Expression Profiling</term><term>Genetic Loci</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Refractive Errors (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Environnement</term><term>Humains</term><term>Locus génétiques</term><term>Niveau d'instruction</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Population d'origine asiatique (génétique)</term><term>Population d'origine européenne (génétique)</term><term>Prédisposition génétique à une maladie</term><term>Troubles de la réfraction oculaire (génétique)</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asian Continental Ancestry Group</term><term>European Continental Ancestry Group</term><term>Polymorphism, Single Nucleotide</term><term>Refractive Errors</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Polymorphisme de nucléotide simple</term><term>Population d'origine asiatique</term><term>Population d'origine européenne</term><term>Troubles de la réfraction oculaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Educational Status</term><term>Environment</term><term>Gene Expression Profiling</term><term>Genetic Loci</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Environnement</term><term>Humains</term><term>Locus génétiques</term><term>Niveau d'instruction</term><term>Prédisposition génétique à une maladie</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (<italic>FAM150B-ACP1</italic>, <italic>LINC00340</italic>, <italic>FBN1</italic>, <italic>DIS3L-MAP2K1</italic>, <italic>ARID2-SNAT1</italic> and <italic>SLC14A2</italic>) associated with refractive error. In Asian populations, three genome-wide significant loci <italic>AREG</italic>, <italic>GABRR1</italic> and <italic>PDE10A</italic> also exhibit strong interactions with education (<italic>P</italic><8.5 × 10<sup>−5</sup>), whereas the interactions are less evident in Europeans. 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Bowes Rickman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rivas, M A" uniqKey="Rivas M">M. A. Rivas</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Croatie</li><li>Estonie</li><li>Finlande</li><li>France</li><li>Hong Kong</li><li>Inde</li><li>Italie</li><li>Japon</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Singapour</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Aquitaine</li><li>Finlande-Centrale</li><li>Grand Londres</li><li>Nouvelle-Aquitaine</li><li>Uusimaa</li></region><settlement><li>Bordeaux</li><li>Cambridge</li><li>Helsinki</li><li>Jyväskylä</li><li>Londres</li><li>Sha Tin</li></settlement><orgName><li>University College de Londres</li><li>Université chinoise de Hong Kong</li><li>Université d'Helsinki</li><li>Université de Bordeaux</li><li>Université de Cambridge</li><li>Université de Jyväskylä</li></orgName></list><tree><noCountry><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><name sortKey="Huffman, Jenifer E" sort="Huffman, Jenifer E" uniqKey="Huffman J" first="Jenifer E." last="Huffman">Jenifer E. Huffman</name><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name></noCountry><country name="Singapour"><noRegion><name sortKey="Fan, Qiao" sort="Fan, Qiao" uniqKey="Fan Q" first="Qiao" last="Fan">Qiao Fan</name></noRegion><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><name sortKey="Barathi, Veluchamy A" sort="Barathi, Veluchamy A" uniqKey="Barathi V" first="Veluchamy A." last="Barathi">Veluchamy A. Barathi</name><name sortKey="Barathi, Veluchamy A" sort="Barathi, Veluchamy A" uniqKey="Barathi V" first="Veluchamy A." last="Barathi">Veluchamy A. Barathi</name><name sortKey="Barathi, Veluchamy A" sort="Barathi, Veluchamy A" uniqKey="Barathi V" first="Veluchamy A." last="Barathi">Veluchamy A. Barathi</name><name sortKey="Beuerman, Roger W" sort="Beuerman, Roger W" uniqKey="Beuerman R" first="Roger W." last="Beuerman">Roger W. Beuerman</name><name sortKey="Beuerman, Roger W" sort="Beuerman, Roger W" uniqKey="Beuerman R" first="Roger W." last="Beuerman">Roger W. Beuerman</name><name sortKey="Beuerman, Roger W" sort="Beuerman, Roger W" uniqKey="Beuerman R" first="Roger W." last="Beuerman">Roger W. Beuerman</name><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><name sortKey="Fan, Qiao" sort="Fan, Qiao" uniqKey="Fan Q" first="Qiao" last="Fan">Qiao Fan</name><name sortKey="Gupta, Preeti" sort="Gupta, Preeti" uniqKey="Gupta P" first="Preeti" last="Gupta">Preeti Gupta</name><name sortKey="Ho, Candice E H" sort="Ho, Candice E H" uniqKey="Ho C" first="Candice E. H." last="Ho">Candice E. H. Ho</name><name sortKey="Ikram, M Kamran" sort="Ikram, M Kamran" uniqKey="Ikram M" first="M. Kamran" last="Ikram">M. Kamran Ikram</name><name sortKey="Ikram, M Kamran" sort="Ikram, M Kamran" uniqKey="Ikram M" first="M. Kamran" last="Ikram">M. Kamran Ikram</name><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><name sortKey="Lim, Wan E" sort="Lim, Wan E" uniqKey="Lim W" first="Wan'E" last="Lim">Wan'E Lim</name><name sortKey="Sabanayagam, Charumathi" sort="Sabanayagam, Charumathi" uniqKey="Sabanayagam C" first="Charumathi" last="Sabanayagam">Charumathi Sabanayagam</name><name sortKey="Sabanayagam, Charumathi" sort="Sabanayagam, Charumathi" uniqKey="Sabanayagam C" first="Charumathi" last="Sabanayagam">Charumathi Sabanayagam</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Siantar, Rosalynn" sort="Siantar, Rosalynn" uniqKey="Siantar R" first="Rosalynn" last="Siantar">Rosalynn Siantar</name><name sortKey="Siantar, Rosalynn" sort="Siantar, Rosalynn" uniqKey="Siantar R" first="Rosalynn" last="Siantar">Rosalynn Siantar</name><name sortKey="Tai Hui Boh, Eileen" sort="Tai Hui Boh, Eileen" uniqKey="Tai Hui Boh E" first="Eileen" last="Tai-Hui Boh">Eileen Tai-Hui Boh</name><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><name sortKey="Tan, Vincent" sort="Tan, Vincent" uniqKey="Tan V" first="Vincent" last="Tan">Vincent Tan</name><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><name sortKey="Wang, Xu" sort="Wang, Xu" uniqKey="Wang X" first="Xu" last="Wang">Xu Wang</name><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><name sortKey="Zhou, Lei" sort="Zhou, Lei" uniqKey="Zhou L" first="Lei" last="Zhou">Lei Zhou</name></country><country name="Pays-Bas"><noRegion><name sortKey="Verhoeven, Virginie J M" sort="Verhoeven, Virginie J M" uniqKey="Verhoeven V" first="Virginie J. 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Williams</name><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name></country><country name="Allemagne"><noRegion><name sortKey="Hohn, Rene" sort="Hohn, Rene" uniqKey="Hohn R" first="René" last="Höhn">René Höhn</name></noRegion><name sortKey="Blettner, Maria" sort="Blettner, Maria" uniqKey="Blettner M" first="Maria" last="Blettner">Maria Blettner</name><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B." last="Jonas">Jost B. Jonas</name><name sortKey="Mazur, Johanna" sort="Mazur, Johanna" uniqKey="Mazur J" first="Johanna" last="Mazur">Johanna Mazur</name><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><name sortKey="Meitinger, Thomas" sort="Meitinger, Thomas" uniqKey="Meitinger T" first="Thomas" last="Meitinger">Thomas Meitinger</name><name sortKey="Mirshahi, Alireza" sort="Mirshahi, Alireza" uniqKey="Mirshahi A" first="Alireza" last="Mirshahi">Alireza Mirshahi</name><name sortKey="Mirshahi, Alireza" sort="Mirshahi, Alireza" uniqKey="Mirshahi A" first="Alireza" last="Mirshahi">Alireza Mirshahi</name><name sortKey="Oexle, Konrad" sort="Oexle, Konrad" uniqKey="Oexle K" first="Konrad" last="Oexle">Konrad Oexle</name><name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S." last="Ried">Janina S. Ried</name><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name></country><country name="Suisse"><noRegion><name sortKey="Hohn, Rene" sort="Hohn, Rene" uniqKey="Hohn R" first="René" last="Höhn">René Höhn</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Yamashiro, Kenji" sort="Yamashiro, Kenji" uniqKey="Yamashiro K" first="Kenji" last="Yamashiro">Kenji Yamashiro</name></noRegion><name sortKey="Meguro, Akira" sort="Meguro, Akira" uniqKey="Meguro A" first="Akira" last="Meguro">Akira Meguro</name><name sortKey="Miyake, Masahiro" sort="Miyake, Masahiro" uniqKey="Miyake M" first="Masahiro" last="Miyake">Masahiro Miyake</name><name sortKey="Mizuki, Nobuhisa" sort="Mizuki, Nobuhisa" uniqKey="Mizuki N" first="Nobuhisa" last="Mizuki">Nobuhisa Mizuki</name><name sortKey="Yoshimura, Nagahisa" sort="Yoshimura, Nagahisa" uniqKey="Yoshimura N" first="Nagahisa" last="Yoshimura">Nagahisa Yoshimura</name></country><country name="Canada"><noRegion><name sortKey="Hosseini, S Mohsen" sort="Hosseini, S Mohsen" uniqKey="Hosseini S" first="S Mohsen" last="Hosseini">S Mohsen Hosseini</name></noRegion><name sortKey="Paterson, Andrew D" sort="Paterson, Andrew D" uniqKey="Paterson A" first="Andrew D." last="Paterson">Andrew D. 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Tam</name><name sortKey="Yap, Maurice K H" sort="Yap, Maurice K H" uniqKey="Yap M" first="Maurice K. H." last="Yap">Maurice K. H. Yap</name><name sortKey="Yip, Shea Ping" sort="Yip, Shea Ping" uniqKey="Yip S" first="Shea Ping" last="Yip">Shea Ping Yip</name><name sortKey="Young, Alvin L" sort="Young, Alvin L" uniqKey="Young A" first="Alvin L." last="Young">Alvin L. Young</name><name sortKey="Young, Alvin L" sort="Young, Alvin L" uniqKey="Young A" first="Alvin L." last="Young">Alvin L. Young</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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